Dr. Priya Suboj

Asst. Prof. and Research Guide - Department of Botany & Biotechnology 

 

Academic Qualifications

1. B.Sc Microbiology, Sub: Zoology & Chemistry - Kannur University - 2002
2. M.Sc Biotechnology - Kannur University - 2005
3. Ph.D - Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST) - Thesis: Molecular Evidence for Anticancer Activity of Aloe Emodin in Colon Cancer Cells - 2012
4. Post Doctoral Research - Edwin L. Steele Laboratory, Massachusetts General Hospital, Harvard Medical School, Harvard - Thesis: Tumor Micro Environment and Tumor Immunology - 2013-2015

Total Teaching Experience

• Assistant Professor - St.Xavier’s College, Thumba - 2012-2013
• Post Doctoral Fellow - Massachusetts General Hospital, Harvard Medical School, Harvard - 2013-2015
• Assistant Professor - St.Xavier’s College, Thumba - 2015 onwards
  
  

Research Experience

Research Fellow - Edwin L. Steele Laboratory, Massachusetts General Hospital, Harvard Medical School, Harvard - 2013-2015
Area of Research: Cancer Biology

Publications

1. Incio J, Liu H, Priya Suboj, Chin SM, Chen IX, Pinter M, Ng MR, Nia HT, Grahovac J, Kao S, Babykutty S, Huang Y, Jung K, Rahbari NN, Han X, Chauhan VP, Martin JD, Kahn J, Huang P, Desphande V, Michaelson J, Michelakos TP, Ferrone CR, Soares R, Boucher Y, Fukumura D, Jain RK. Obesity-induced inflammation and desmoplasia promote pancreatic cancer progression and resistance to chemotherapy. Cancer Discovery. 2016 May 31. pii: CD-15-1177. [Epub ahead of print]
2. Incio J, Tam J, Rahbari NN,Priya Suboj, McManus DT, Chin SM, Vardam TD, Batista A, Babykutty S, Jung K, Khachatryan A, Hato T, Ligibel JA, Krop IE, Puchner SB, Schlett CL, Hoffmman U, Ancukiewicz M, Shibuya M, Carmeliet P, Soares R, Duda DG, Jain RK, Fukumura D. PlGF/VEGFR-1 Signaling Promotes Macrophage Polarization and Accelerated Tumor Progression in Obesity. Clin Cancer Res. 2016 Jun 15;22(12):2993-3004. doi: 10.1158/1078-0432.CCR-15-1839. Epub 2016 Feb 9
3. Incio J, Priya Suboj, Chin SM, Vardam-Kaur T, Liu H, Hato T, Babykutty S, Chen I, Deshpande V, Jain RK, Fukumura D. Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages. PLoS One. 2015 Dec 7;10(12):e0141392. doi: 10.1371/journal.pone.0141392. e Collection 2015
4. Priya Suboj, Suboj Babykutty, V.G. Deepak Roshan, Rakesh S. Nair, Priya Srinivas, Srinivas Gopala; Aloe emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB and VEGF via reduced DNA binding activity of NF-kB. European Journal of Pharmaceutical Sciences, 45(5):581-591, (2012)
5. Priya Suboj, Suboj Babykutty, PriyaSrinivas, SrinivasGopala; Aloe emodin induces G2/M cell cycle arrest, and apoptosis via activation of caspase- 6 in human colon cancer cells. Pharmacology;89:91–98, (2012)
6. Suboj Babykutty, Priya Suboj, Asha S Nair, Chandra Mohan K, PriyaSrinivas, SrinivasGopala; Nitric oxide enhances migration/invasion of colon cancer cells by upregulating MMP-2/9 via activation of the cGMP-PKG-ERK signaling pathways. Clinical and Experimental Metastasis, 29(5):471-92, (2012)
7. Suboj Babykutty, Priya Suboj, Nandini.R.J, Suresh Kumar M.A, Mangalam Nair, PriyaSrinivas, SrinivasGopala; Nimbolide retards tumor cell migration, invasion and angiogenesis by downregulating MMP-2/9 expression via inhibiting ERK1/2 and reducing DNA binding activity of NF-κB in colon cancer cells. Molecular Carcinogenesis, 51(6):475-90, (2012)
8. Suboj Babykutty,Jose Padikkala, Priya P. S,VinodVijayakurup, T. K. Abdul Azis, PriyaSrinivas, SrinivasGopala; Apoptosis induction of centellaasiatica on human breast cancer cells. African Journalof Traditional Complementaryand Alternative Medicine,6(1):9-16, (2008)
9. SrinivasGopal, Suboj Babykutty, PriyaP.S, PriyaSrinivas, Molecular mechanism of emodin action: transition from laxative ingredient to an antitumor agent. Medicinal Research Reviews. 27(5):591-608, (2007)

Abstracts

1. 1. Suboj Babykutty,PriyaPrasannaSathiadevan, SrinivasGopala; Insidious role of nitric oxide in matrix digestion/migration through cGMP-ERK-AP1 pathway in colon cancer cells. 23rd Kerala Science Congress, Dec 21-23, (2010)
2. PriyaP.S, Suboj Babykutty, VinodVijayakurup, Padmakrishnan. C. J, PriyaSrinivas, GopalSrinivas; Aloe emodin, a versatile anthraquinone targeting multiple facets (apoptosis, metstasis, angiogenesis) of cancer progression. ECCO 15 -ESMO 34 Multidisciplinary Congress, Berlin, European Journal of Cancer Supplements, Vol 7 No 2, Page 95, (2009)
3. Suboj Babykutty, PriyaP.S, VinodVijayakurup, Padmakrishnan. C. J, PriyaSrinivas, GopalSrinivas; Nitric oxide-cGMP-MMP2/9 circuit in colon cancer migration and invasiveness: An in vitro study. ECCO 15 -ESMO 34 Multidisciplinary Congress, Berlin, (2009)
4. Priya P.S, Suboj Babykutty, Gopal Srinivas; Anticancer activity of aloe emodin in colon cancer cells- an invitro study: Proceedings of the 21 st Kerala Science Congress, January, kollam, pp 546-548, (2009)
5. PriyaP. S, Suboj Babykutty, VinodVijayakurup, PriyaSrinivas, GopalSrinivas; In vitro Anticancer activity of aloe emodin involves G2/M arrest and inhibition of metastasis in colon cancer cells. International PSE symposium on Natural Products in Cancer Therapy, Italy, (Published in European Journal of Cancer Supplements, Vol 7 No 2, September 2009, Page 95) (2008)
6. Suboj Babykutty, Priya P.S, VinodVijayakurup, PriyaSrinivas, GopalSrinivas; Dynamics of Matrix metalloproteinase gene expression by nitric oxide: involvement of cGMP pathway. Cancer Degredome, London, (2008)

 Review

SrinivasGopal, Suboj Babykutty, PriyaP.S, priyaSrinivas, Molecular mechanism of emodin action: transition from laxative ingredient to an antitumor agent. Med Res Rev. Sep; 27(5): 591-608, (2007)

Academic and Professional Honors

1. 2010 - Best poster award in National science day symposium, Kerala, India
2. 2008 - Best poster award in International PSE symposium on Natural Products in Cancer Therapy, Italy
3. 2006 - Shyama Prasad Mukherjee award nominee, CSIR, Govt. of India
4. 2006 - Junior Research Fellowship (JRF), CSIR, Govt. of India
5. 2004 - GATE-Qualified